I try to keep the same .zshrc dotfile on all the machines I use. I store the “master” copy in SVN, so any improvements I make can easily go to other computers.
However, some parts of zshrc configuration only make sense for particular machine. To keep one common master copy but also allow for some “local” configuration, you can simply use an include in your .zshrc like this:

[[ -r ~/.zsh/local.zsh ]] && . ~/.zsh/local.zsh